Effects of Hydrogen-ionized Silica Intake on Blood Biomarkers in Adults: Multinational Exploratory Study of Korea, Japan..

Abstract

Purpose: Oxidative stress and chronic inflammation have recently been recognized as major underlying mechanisms of various chronic diseases, leading to growing interest in antioxidant materials capable of modulating these processes. Although hydrogen and silica have individually been reported to exhibit antioxidant and physiological effects, human studies investigating Hydrogen-ionized Silica, a combined aqueous formulation of these substances, remain limited. Therefore, this study aimed to investigate the effects of Hydrogen-ionized Silica intake on physiological blood biomarkers in adults and to explore potential metabolic and physiological responses, including differences according to country.

Method: This study employed a single-group pre–post intervention design involving adults from South Korea, Japan, Taiwan, and Thailand. A total of 32 participants consumed Hydrogen-ionized Silica for 6 weeks. Pre- and post-intervention blood test results were analyzed to assess hematological parameters, immune and inflammatory markers, liver and renal function markers, and metabolic and lipid-related indicators. Data were analyzed using the Wilcoxon signed-rank test, Mann–Whitney U test, and Kruskal–Wallis test following normality testing.

Results: The findings indicated that most blood biomarkers did not show significant pre–post changes following Hydrogen-ionized Silica intake. However, significant changes were observed in fasting glucose and eosinophil levels. In addition, analyses according to sex, age, and country demonstrated no significant differences for most variables.

Conclusion: Hydrogen-ionized Silica intake appeared to demonstrate limited changes in specific metabolic and immune-related biomarkers rather than broad effects across overall blood biochemical parameters. These findings provide exploratory baseline evidence regarding the physiological effects of Hydrogen-ionized Silica and may serve as preliminary data for future systematic investigations.

Keywords: Hydrogen-ionized Silic, Blood Glucos, Blood Biomarkers, Antioxidants, Oxidative Stress